Arylesterase activity of paraoxonase 1 (PON1) on HDL3 and HDL2: Relationship with Q192R, C-108T, and L55M polymorphisms
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چکیده
منابع مشابه
Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms.
OBJECTIVE This study aims to investigate the effect of cigarette smoking on paraoxonase 1 (PON1) activity according to PON1 L55M and PON1 Q192R gene polymorphisms. MATERIALS AND METHODS Our sample included 300 voluntary subjects: 138 nonsmokers and 162 current smokers aged 38.47 ± 21.91 and 35.55 ± 16.03 years, respectively. PON1 activity was determined by kinetic methods. L55M and Q192R gene...
متن کاملParaoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder
Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disord...
متن کاملArylesterase activity and antioxidant status depend on PON1-Q192R and PON1-L55M polymorphisms in subjects with increased risk of cardiovascular disease consuming walnut-enriched meat.
Human paraoxonase (PON1) exists in 2 major polymorphic forms and has been shown to protect LDL and HDL against oxidation. The aim of this study was to assess the differences between subjects at increased risk of cardiovascular disease (CVD), taking into account the effects of PON1-Q192R and PON1-L55M polymorphisms on 1) basal serum arylesterase activity, lipid peroxidation (LPO), and LDL-choles...
متن کاملAssociation of Homocysteine, Asymmetric Dimethylarginine and L55M and Q192R Polymorphisms of Paraoxonase-1 Gene with Preeclampsia
Objective: Preeclampsia is a major cause of maternal and fetal mortality worldwide. A reliable test that would identify the "at risk" group of pregnant women is not available. Homocysteine and ADMA have been shown to be elevated in disorders characterized by endothelial dysfunction including preeclampsia. Paraoxonase 1 is though to influence serum homocysteine and to play a role in preeclampsia...
متن کاملAssociation of paraoxonase-1(Q192R and L55M) gene polymorphisms and activity with colorectal cancer and effect of surgical intervention.
BACKGROUND Colorectal cancer (CRC) is a leading cause of cancer-related death. Oxidative DNA damage may contribute to cancer risk and the antioxidant paraoxonase is one endogenous free radical scavenger in the human body which could therefore exert an influeence. PURPOSE Aim of this study was to determine the role of serum arylesterase (ARE) and paraoxonase 1(PON1) activities in CRC patients ...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2021
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2021.100971